Almost 12 months ago I started having bouts of extreme diarrhea. I spoke to my General Practitioner and then my specialist. Several suggestions were made which took me down several different avenues. One being gluten intolerance - so I changed what I was eating and removed gluten from my diet - oats, barley, wheat & rye. But though it was reduced it was still occurring and I went off and had an allergy test to see if I did have an allergy to gluten - which I apparently didn't. So what was causing the problem. After losing nearly 10kg, I was feeling pretty terrible. A diet is great but this was not fun. I spoke to my specialist again and he suggested I stop taking the Ursofalk. So about October 2010, I stopped taking the medication and stayed off for about 2 1/2 months - during which time, I didn't have any symptoms and was feeling a heap better. As my specialist had told me that I could only go off them for a maximum of 3 months, like a good girl I started taking them again about 14 days ago. Some of the symptom have come back - stomach not feeling right, loose bowel motions, flatulence. I would be interested to know if other people who are taking Ursofalk have also had these symptoms. I can't go through that again, but at the same time I need to take something for the PBC!!!